| No. Registro | 002315048 |
| Tipo de material | TRABALHO DE EVENTO-RESUMO PERIODICO - INTERNACIONAL |
| Entrada Principal |  Lira, Fabio (*) |
| Título | Neuropeptides, metabolic disorder and inflammation in colon cancer patients : contributing to the cachexia syndrome. |
| Imprenta | Milão : Society on Sarcopenia, Cachexia and Wasting Disorders, 2011. |
| Descrição | p. 3-11. |
| Idioma | Inglês |
| Assunto | PERDA DE PESO |
| | NEUROPEPTÍDEOS |
| | DOENÇAS METABÓLICAS |
| | NEOPLASIAS DO COLON |
| Autor Secundário | Silvério, R. (*) |
| | Oyama, L. (*) |
| | Nascimento, C. O. (*) |
| | Batista, M. (*) |
| | Laviano, A. (*) |
| | Rossi-Fanelli, F. (*) |
| | Alcântara, P. (*) |
| | Otoch, J. (*) |
| | Seelaender, Marilia Cerqueira Leite |
| Autor Secundário | Cachexia Conference (6. 2012 Milão) |
| Fonte | In: Journal of Cachexia, Sarcopenia and Muscle, v. 2, n. 4, p. 209-261, 2011 |
| Localiz.Eletrônica |
 "Clicar" sobre o ícone para acessar o Currículo Lattes de Marilia Cerqueira Leite Seelaender |
| Resumo/Outros | Background and aims: Cancer cachexia, a devastating wasting syndrome, affects around 50% of all cancer patients and up to 80% of those with the advanced form of the disease. Inflammation plays a pivotal role in cachexia affecting the control of central energy balance, tissue metabolism and function, and modulation of appetite. This study aimed to examine plasma lipid profile, neuropeptides, and inflammatory marker levels in cancer patients with and without cachexia. Methods: Forty-five subjects (control n=15, tumour-bearing patients without cachexia n=15, and tumour-bearing cachectic patients n=15). Samples were obtained from male and female patients, 18–100 years with gastrointestinal tumour, who underwent surgery at University Hospital (University of São Paulo). Approximately 10 mL of blood were collected in the surgical procedure within the venous access procedure of anaesthesia. The plasma lipid profile (Triglycerides, HDL-cholesterol, total cholesterol, NEFA), glucose, insulin, HOMA-IR, PAI-1, endotoxin, MSH, MCH and NPY levels were determined (Kits ELISA and colorimetric methods). |
| | Results: Total cholesterol levels were increased in tumour-bearing (without and with cachexia) patients (p<0.05). In addition, NEFA and PAI-1 levels were increased in cachectic patients only (p<0.05). In contrast, all neuropeptides assessed (MCH, MCH, and NPY) were decreased in cachectic tumour-bearing patients, as compared with the control group (p<0.05). Conclusion: These results indicate that cachectic cancer patients exhibit alterations in metabolism, inflammation and modified neurohormonal control of food intake, favouring the aggravation of the syndrome. |
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| Unidade USP | ICB -- INSTITUTO DE CIÊNCIAS BIOMÉDICAS |
