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Escolher formato: Padrão Ficha Formato Reduzido Nomes MARC Campos MARC
No. Registro   002142550
Tipo de material   TRABALHO DE EVENTO - NACIONAL
Entrada Principal   LinkMonteiro, Mariana Marin (*)
Título   LinkShort- and long-term morphological alterations promoted by diabetes mellitus in rat salivary glands.
Imprenta   São Paulo : Sociedade Brasileira de Biologia Celular, 2010.
Descrição   p.50 res. C-81.
Idioma   Inglês
Assunto   LinkHISTOLOGIA
Autor Secundário   LinkLamers, Marcelo Lazzaron (*)
  LinkD’Epiro, Talyta Tereza Soares (*)
  LinkNicolau, José (*)
  LinkSantos, Marinilce Fagundes dos
Autor Secundário   LinkMeeting of the Brazilian Society for Cell Biology - SBBC (15. 2010 São Paulo)
Fonte   LinkIn: Program & Abstracts, São Paulo: Sociedade Brasileira de Biologia Celular, 2010
Localiz.Eletrônica    "Clicar" sobre o botão para acesso ao Currículo Lattes Marinilce Fagundes dos Santos 
Resumo/Outros   The chronic hyperglycemia that characterizes Diabetes MeJlitus (DM) affects the homeostasis and function of many organs, including salivary glands and kidneys. Oral manifestations of DM are often secondary to the hipofunction of salivary glands. The aim of this study was to evaluate morphological and extraceJlular matrix alterations in the parotid and submandibular gland (SMG) of adult male diabetic rats for 30 (D30) and 180 (D180) days, correlating with renal alterations. DM was induced by streptozotocin injection (60mg/kg weight). Food intake, body weight, urinary volume, glycosuria and glycemia were evaluated. Fragments from the organs were fixed, processed and embedded in Paraplast®. Five im-sections were submitted to HE staining and imunohistochemistry for laminin and collagen type 111. Morphometric analysis was performed in the SMG. Clear vacuoles were observed in acinar ceJls of the parotid gland, mainly in D30. In the SMG a decrease in the volume of convoluted granular ducts and a discrete increase of acinar volume was observed both in D30 and D180. Morphological alterations were not directly correlated with same augment of laminin was observed in renal glomeruli, increasing progressively over time. These results suggest that salivary glands are more capable than kidneys to adapt to long term hyperglycemia
 
Unidade USP   ICB -- INST DE CIÊNCIAS BIOMÉDICAS

Escolher formato: Padrão Ficha Formato Reduzido Nomes MARC Campos MARC


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