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Escolher formato: Padrão Ficha Formato Reduzido Nomes MARC Campos MARC
No. Registro   001606354
Tipo de material   ARTIGO DE PERIODICO - INTERNACIONAL
Cód. publicação   Link10.1016/j.powtec.2006.09.007 DOI
Entrada Principal   LinkRattes, Alysson Leandro Ribeiro (*)
Título   LinkSpray drying conditions and encapsulating composition effects on formation and properties of sodium diclofenac microparticles.
Imprenta   Lausanne, 2007.
Descrição   p. 7-14.
Idioma   Inglês
Assunto   LinkANTI-INFLAMATÓRIOS
  LinkMEDICAMENTO (PREPARO)
Autor Secundário   LinkOliveira, Wanderley Pereira de
Fonte   LinkIn: Powder Technology, Lausanne, v. 171, p. 7-14, 2007, ISSN: 0032-5910
Localiz.Eletrônica   e-mail do autor -- mailto://wpoliv@fcfrp.usp.br
Localiz.Eletrônica    "Clicar" sobre o botão para acesso ao Currículo Lattes de Wanderley Pereira de Oliveira 
Resumo/Outros   This paper reports the preparation and characterization of sustained release sodium diclofenac microparticles by spray drying. Aqueous dispersions of ethyl cellulose (Surelease) and Eudragit RS 30 D were evaluated as controlled release polymers. The product properties (product moisture, size distribution, particle morphology, flow properties, total drug load, in-vitro dissolution studies, and encapsulating efficiency) were determined as a function of inlet temperature of the spray drying, the feed flow rate and composition of the microencapsulating formulation. In general, lower values of the product moisture content were observed at higher drying temperatures. The spray-dried product was composed mainly by rounded-shape and multi-size particles. The mean particle diameters of the Eudragit based microparticles tended to be slight bigger than the Surelease based microparticles. The spray dried microparticles showed delayed drug dissolution rates, sustaining the drug release for several hours. These findings confirm the feasibility of the spray drying for preparation of microparticles with sustained release properties. The physical and chemical properties of the microparticles can be changed by varying the spray drying parameters as well as the microencapsulating formulation
 
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Itens na Biblioteca   BCRP-Fac Ciên Farmac Rib PretLibrary Info
Unidade USP   FCFRP -- FAC DE CIÊNCIAS FARMACÊUTICAS DE RIBEIRÃO PRETO

Escolher formato: Padrão Ficha Formato Reduzido Nomes MARC Campos MARC


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