| No. Registro | 001223062 |
| Tipo de material | ARTIGO DE PERIODICO - INTERNACIONAL |
| Entrada Principal |  Nery, Marlene Maria Fregonezi (*) NAC |
| Título | Determination of albendazole in oral suspension. |
| Imprenta | New York, 2001. |
| Descrição | p. 1255-1263. |
| Idioma | Inglês |
| Assunto | SUSPENSÃO |
| | MEDICAMENTO |
| | CROMATOGRAFIA LÍQUIDA (MÉTODOS) |
| | FARMACOLOGIA |
| Autor Secundário | Baracat, Marcela Maria (*) NAC Universidade Estadual de Londrina - Departamento de Tecnologia de Alimentos e Medicamentos - Centro de Ciências Agrárias, Londrina, PR, Brasil |
| | Kedor-Hackmann, Erika Rosa Maria |
| | Pinheiro, Rafael Mota (*) NAC Universidade Estadual de Londrina - Departamento de Tecnologia de Alimentos e Medicamentos - Centro de Ciências Agrárias, Londrina, PR, Brasil |
| Fonte | In: Analytical Letters, New York, v. 34, n. 8, p. 1255-1263, 2001, ISSN: 0003-2719 |
| Localiz.Eletrônica | e-mail do autor -- mailto://ismael@cambenet.com.br |
| | e-mail do autor -- mailto://nery@uel.br |
| Resumo/Outros | Albendazole is a potent benzimidazole anthelmintic used in the treatment of human intestinal helmintiasis as well as of hydatid cysts and neurocysticercosis. Two analytical methods were standardized for determination of albendazole in pharmaceutical preparations (oral suspension), one by UV direct spectrophotometry at 230 nm using as solvent 2% sulfuric acid in methanol, and another by HPLC using a Nucleosil((R)) C18 (5 mu - 4.6 x 150 mm) Phenomenex((R)) column, and a mobile phase consisting of methanol: 0.05 M phosphate buffer (70:30; v/v), UV detection at 254 nm and ambient temperature. The methods were applied to simulated and commercially available samples and the results were statistically compared showing that both methods were accurate and sensitive and there was no significant difference between them |
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| Unidade USP | FCF -- FAC DE CIÊNCIAS FARMACÊUTICAS |
